Biomedical Letters

Anti-breast cancer therapy may affect blood and liver cells

Muhammad Younis 1,2, Raza Abbas 3, Amjad Hussain 2, Sana Shaikh Mehmood 2, Imtiaz-ul-Hassan 2, Muhammad Iqbal 4, Neelma Shoukat 2, Arsalan Nizamani 5, Fawad ur Rehman 6, Khawar Ali Shahzad 7*

1 The key Laboratory of Development Genes and Human Diseases, Institute of Life Sciences, Southeast University, Sipailou 2, Nanjing, 210096, China

2 Institute of Biochemistry, University of Sindh, Jamshoro, Sindh, Pakistan

3 School of Biological and Environmental Engineering, Nanjing University of Science and Technology, Nanjing, China

4 Liaquat University of Medical and Health Sciences, Jamshoro, 76090, Sindh, Pakistan

5 HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Sindh, Pakistan

6 State key laboratory of bioelectronics, School of biological science and medical engineering, Southeast University, Sipailou 2, Nanjing, 210096, China

7 Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

Abstract

Chemotherapy and radiations for breast cancer destroy constantly dividing breast cancer cells. However, these treatments can also affect healthy cells of the patient. Stages of breast cancer range from early cure of metastatic breast cancer, with a variety of treatments. Chemotherapy affects normal, healthy cells as well as breast cancer cells; because of this reason, it may cause hair loss, anemia, and diarrhea. Our study shows the risk of developing anemia, leukemia and liver disease after radiation therapy or chemotherapy to treat early-stage breast cancer, A total of 90 blood samples from control and cancer patients were collected and analyzed for RBCs, WBCs, Platelets, absolute indices and liver function test. Hematological analyzer Sysmex KX-21N used for hematological studies and commercial kits for Pioneer Diagnostics is used for liver function tests. It was concluded that anti-cancer treatments such can affect in RBCs, WBCs, platelets, absolute indices and liver function test. Low levels of these cells can result in the immunocompromised body of the cancer patient.

Key word: Breast cancer, chemotherapy, radiotherapy, liver.

Received November 06, 2014 Revised December 02, 2014 Accepted January 11, 2015

*Correspondence: Khawar Ali Shahzad Email: khawar7bar@yahoo.com Contact: 0086-13915994014, 0092-3007311511