Biomedical Letters

Application of Injectable Calcium Phosphate Cement with rhBMP-2 in the Elder Patients with Tibial Plateau Fractures

Delwa Kassire Coumakoye Abdelsalam, Liu Li Feng, Pan yu Tao, Chen Di, Li Xia, Li Zeng Chun*

Department of Emergency Medicine and Traumatology, The Affiliated East Hospital of Tongji University, Shanghai 200120, China

Abstract

The tibial plateau fractures pose a therapeutic appeal. These fractures are often left with a large bone defect area after fracture reduction and articular surface restoration. Here we assessed the effect and safety of bone grafting with injectable calcium phosphate cement (CPC) with recombinant human bone morphogenetic protein (rhBMP-2) in 59 elderly patients with tibial plateau fractures. Fifty-nine tibial plateau fractures were treated by CPC with rhBMP-2 (experimental group) or CPC (control group) with open reduction internal fixation (ORIF). The difference between two groups in terms of Lane-Sandhu criterion and the function of the knee joint were compared. The mean period of follow-up was 14.2 months. All local incision had no itch sensation or pain. The experimental group average period of bone healing was 20.8 weeks, and the control group was 25.8 weeks. There was the obvious significant difference between the two groups in terms of Lane-Sandhu criterion. Moreover, the function of the knee joint was better. One year after an operation according to Rasmussen joint function grading. There was the obvious significant difference between the two groups (P<0.05). The mixture of Calcium phosphate cement with recombinant human bone morphogenic protein (rhBMp-2/CPC) is safe, convenient, and has less complications. The combination of material has better support for bone defect area after solidification and increases the safety of functional motion at an early stage. Meanwhile, rhBMP-2/CPC can be the suitable bone substitutions for a bone defect in elderly patients with tibial plateau fractures.

Keywords: calcium phosphate cement, bone morphogenic protein-2, bone substitution, tibial plateau fractures.

Received January 31, 2017 Revised March 15, 2017 Accepted March 23, 2017

*Correspondence: Li Zeng Chun Email abkasscou@163.com Contact: +8613310054120