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ISSN 2410-955X - An International Biannual Journal
Recent progress in neurodegenerative diseases via exosomal therapy
Aqsa Qambrani*
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
Abstract
Exosomes are the type of extracellular vesicles (EV) found almost in every type of biological fluid from human blood to saliva and semen. These EVs are rich in various kinds of nucleic acids such as DNA, RNA and proteins. They mediate in cell-to-cell communication and transfer cargo to different cells and tissues. In the brain, they perform a variety of functions i.e., synaptic plasticity, neuronal stress response and neurogenesis. Though much research has been carried on exosomes revealing their character in tumor proliferation and neurodegenerative diseases, their exact role and function in mental disorders remains scarce. Exosomes are permeable to blood-brain barrier due to this permeability they be hypothesized as potential biomarkers of neural dysfunction. Study on exosomes precisely those derived from the brain may deliver information about theranostic and may offer a mechanistic approach of the phenotype of the disorder. In this review paper, we highlight the role of exosomes in neural degenerative diseases.
A R T I CL E I N F O
Received
October 29, 2019
Revised
December 03, 2019
Accepted
December 12, 2019
*Corresponding Author
Aqsa Qambrani
E-mail
aqsa.qambrani@yahoo.com
Keywords
Exosomes
Extracellular vesicles
Semen
Neuronal stress
Mental disorders
Skeletal pattern
Review article
2019 | Volume 5 | Issue 2