Science Letters

Hematological study of cancer patients with radio-chemotherapy

Muhammad Iqbal 1, Muhammad Younis 2, 3, Neelma Shoukat 3, Sana Shaikh 3, Nida Akram 2, Raza Abbas 4, Khawar Ali Shahzad 5, Kanwal Mazhar 6, Fawad ur Rehman 7*

1 Liaquat University of Medical and Health Sciences, Jamshoro, 76090, Sindh, Pakistan

2 The key laboratory of development genes and human disease, Institute of Life Sciences, Southeast University, Sipailou 2, Nanjing, 210096, China

3 Institute of Biochemistry, University of Sindh, Jamshoro, Sindh, Pakistan

4 School of biological and Environmental Engineering, Nanjing University of Science and Technology, China

5 Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

6 Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China

*7 State key lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Sipailou 2, Nanjing 210096, China

Abstract

Cancer is a complex disease with multiple triggers and high mortality rate all over the world. Currently Chemotherapy, radiotherapy and invasive surgeries are in vogue for cancer therapeutics. There are certain delicate parts where the invasive surgeries are a great deal of risk; therefore we only need to rely on chemo and radiotherapy either separately or combined. These therapies in return highly compromise the patient's life quality as adverse effects. Therefore, the current study was conducted to evaluate the radio and chemotherapy effects on the various blood cells correlated properties, i.e., anemia, thrombocytopenia, leucopenia, etc. Our results suggest that radiation and chemotherapy cause decrease in thrombocytes and leukocytes count in cancer treated patients. Total 80 samples were measured by hematological analyzer and found a significant decrease in the hematological parameters (thrombocytes, total leukocyte count, cell volume, and hemoglobin) mean values in cancer treated patients when compared to the healthy individuals. It was concluded that radio-chemotherapy have some serious adverse effects on the health and normal physiology of cancer patients.

Keywords: Cancer, radio-chemotherapy, blood parameters, adverse effects.

Received February 05, 2015 Revised April 13, 2015 Published online first June 15, 2015

*Correspondence Fawad ur Rehman Email dawarvet@hotmail.com