Science Letters

Research Progress and Challenges in Regenerative Orthopedics

Mohammed Ghouse, Sohail Ahmed, Wang Li Min*

Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China

Abstract

Organ and tissue loss due to disease or injury are generating the evolution of various therapies that regenerate the tissues and lower the dependence on transplantation. The whole summary of regenerative orthopedics is a mutual disciplinary field which applies both engineering and the principles of life science to foster the regeneration, can possibly redevelop the injured or diseased tissues or even the whole organ. There are few imperatively important factors in tissue engineering and regenerative medicine such as growth factors, cells and scaffold. The improvement in the field of science and technology has transferred these fundamental researches into clinical practice. We have also further explored tissue regeneration over the past decade by using the model animals, suffering from musculoskeletal disorders by manipulating the cells, scaffold, and delivery systems that are comparatively much easier to utilize and further develop in clinical settings. Computer simulation or in silico models are commonly utilized in regenerative orthopedics and achieved a great success in multiple disease settings. In this review, we would like to introduce, particularly the progress in these models in regenerative medicine. Moreover, we also propose possible tendencies for various therapies on regenerative medicines in the future.