Science Letters

Biomedical Sciences | Research article

Study of Human Cancer Cells, Tissues and Tumors Treatment Through Interaction Between Synchrotron Radiation and Cerium Nanoparticles

Alireza Heidari 1, 2*, Katrina Schmitt 1, Maria Henderson 1, Elizabeth Besana 1

1 Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

2 American International Standards Institute, Irvine, CA 3800, USA

Abstract

The heat transfer phenomena for single- and double-layer inclined absorbers, which absorb synchrotron radiation has been studied using analytical and numerical methods. Photon penetration through the metal layers has been included and the effects of the spectral variation of the absorption coefficients and variable thermal conductivities have been examined. Different thickness ratios and inclination angles have been studied for double layer absorbers and it has been shown that double-layer inclined absorbers significantly reduce the peak temperatures. In the current study, thermoplasmonic characteristics of cerium nanoparticles with spherical, core-shell and rod shapes were investigated. In order to investigate these characteristics, the interaction of synchrotron radiation emission as a function of the beam energy and cerium nanoparticles were simulated using the 3D finite element method. Firstly, absorption and extinction cross-sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in cerium nanoparticles by solving the heat equation. The obtained results showed that cerium nanorods are a more appropriate option for using in optothermal human cancer cells, tissues and tumor treatment methods. Furthermore, the produced heat devastates tumor tissues adjacent to nanoparticles without any hurt to sound tissues. Regarding the simplicity of ligands connection to cerium nanoparticles for targeting cancer cells, these nanoparticles are more appropriate to use in optothermal human cancer cells, tissues and tumors treatment.