Biomedical Letters

Synthesis and Estimation of Enzyme Inhibitory Activity of Isatin Derivatives

Shahana Noshi 1*, Kalsoom Zaigham 1*, Khawar Ali Shahzad 1, 2, Taj Mahmood Rana 3

1 Institute of Molecular Biology and Biotechnology, The University of Lahore, 54000, Lahore, Pakistan

2 Department of Microbiology and Immunology, Southeast University, Nanjing 210009, China

3 Government College Satellite Town Rawalpindi, 46300, Rawalpindi, Pakistan

Abstract

In the present study several derivatives of Isatin (A-L) were synthesized. All the synthesized derivatives (A-L) were Schiff bases and show vital pharmacological properties, suppose beneficial in Alzheimer's disease (AD). The structures were confirmed spectroscopically by infrared (IR) and nuclear magnetic resonance (NMR). The purpose of the current study was to synthesized derivatives which possess acetylcholinesterase and butryl cholinesterase inhibitory potential. Several compounds possess anti-acetylcholinesterase and anti-butryl cholinesterase activity, particularly the compound (J) with malononitrile substituent on Isatin ring was most active in suppressing acetyl cholinesterase enzyme activity and the compound (F) with M-Toluidine substituent on isatin ring was potent inhibitory activity against butryl cholinesterase enzyme.

Keywords: Isatin, amines, Schiff bases, Alzheimer's diseases, BChE inhibitor, AChE inhibitor.

Received January 07, 2016 Revised February 18, 2016 Accepted February 27, 2016

*Correspondence: Shahana Noshi, Kalsoom Zaigham Email chemsn11@gmail.com, kalsimbb@yahoo.com,

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