Biomedical Letters

Recent Approach in Medical Management of Fistulizing Crohn's Disease

Pawan Kumar, Zhanju Liu*

Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China

Abstract

Crohn's disease is increasing in prevalence worldwide despite the biological treatment being associated with improved health related aspect of the human body. Fistulizing Crohn's disease is an emerging but still unclear issue for many authorities that accelerate from a complicated paradox among the genetic predisposition and environmental ramification. In fistulizing Crohn's disease, perianal fistula is very common, which correlate to grief with fatality in life. Thus a brief assessment with proper analysis of database and clinical practice guidelines are to be followed. In addition, with different modern and advanced modalities are required to determine the most suitable groundwork. Exploration undergoes beside the novel medicines and newer approaches, anti-TNF monoclonal antibodies (biologics) and gut selective agents including the dietary and lifestyle modification.

Keywords: Crohn's disease, Perianal fistula, inflammatory bowel disease, anti-TNF therapy.

Received July 21, 2016 Revised August 29, 2016 Accepted September 10, 2016

*Correspondence: Zhanju Liu Email: zhanjuliu@yahoo.com Contact: +86 18917683431 Fax: +86-021-66303983