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Biomedical Letters ISSN 2410-955X
2018 | Volume 4 | Issue 1 | Pages 15-18
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Research article
Effect of Iron over Load on Circulating Liver Enzymes and Blood Glucose in Beta Thalassemia Major Patients
Bashir Ahmad 1, 2*, Nadeem Abbas 1,2, Anas Khalil 1, 2, Farah Deeba Khan 1, 2 

1 Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
2 Department of Biochemistry, University College of Medicine & Dentistry, The University of Lahore, Lahore, Pakistan

Abstract
Thalassemias are a heterogeneous group of disorders with a genetically determined decrease in the rate of production of one or more forms of normal hemoglobin chains. Thalassemia patients need regular blood transfusions for their existence. As a result of frequent blood transfusions majority of the patients develop iron overload. The present work was planned to study liver dysfunctions and blood glucose estimation in patients with β-thalassemia major due to iron overload. Fifty-three individuals (12 to 23 years) were selected from which 43 were beta thalassemia major patients and 10 normal individuals were taken as a control. Serum ALT, AST, ALP, glucose, Hb, and Ferritin were measured. A significant increase (p<0.05) was recorded in levels of ALT, AST, ALP, glucose, and ferritin in β-thalassemia major patients with comparison to control subjects. A significant decrease (p<0.05) was observed in hemoglobin of β-thalassemia patients as compared to control group. The outcomes of the study revealed a rise in ALT, AST, ALP, Glucose and Ferritin levels and a significant decrease in Hb level in β-thalassemia Major patients as compared to control subjects.

A R T I CL E  I N F O

Received
January 07, 2018
Revised
February 27, 2018
Accepted
March 05, 2018

*Corresponding Author
Bashir Ahmad Shaheen
E-mail
bashirahmad886@yahoo.com

Keywords
Liver enzyme
Thalassemia
Glucose
Ferritin
Hemoglobin
ALT