Biomedical Letters

Bioinformatical Detection of Thalassemia and Bone Marrow Transplantation

Tanveer Hussain, Manzoor Hussain, Jonathan Javid*, Abdur Rehman, Muhammad Waqas, Ahitsham Umar, Shahrukh Hassan, Shahrooz Zafar, Muhammad Yousaf Jamal

Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan

Abstract

Thalassemia is considered as a severe blood problem in which unusual type of hemoglobin is produced by the body. It is a protein, present in red blood cells to transport the oxygen. Bioinformatics tools and software are used to detect, predict and visualize the mutation in a single nucleotide polymorphism including for thalassemia. Thalassemia is classified into two types as alpha thalassemia in which the properties of alpha globin altered and beta globin properties are influenced in beta thalassemia. The treatment of thalassemia depends upon the type and severity of the disease. Some of them include blood transfusion, medication and supplements, conceivable medical procedure to evacuate spleen, gall bladder and bone marrow transplantation. The transplantation of bone marrow is a clinical technique includes transplanting blood stem cells, which travel to the bone marrow where they produce fresh recruit cells and develop growth of new marrow about the extracted blood for the transplantation to analyze allogeneic bone marrow and autologous bone marrow transplantation.