Overview of hydroxyapatite; composition, structure, synthesis methods and its biomedical uses
Shafiq Uz Zaman 1, Muhammad Irfan 2*, Masooma Irfan 3*, Nawshad Muhammad 2, Muhammad Khaliq U Zaman 4, Abdur Rahim2, Saif-Ur-Rehman 1
1 Department of Chemical Engineering, COMSATS University Islamabad, Lahore Campus, Pakistan
2 Interdisciplinary Research Center in Biomedical materials, COMSATS University Islamabad, Lahore Campus, Pakistan
3 Department of Chemistry, COMSATS University Islamabad, Lahore Campus 54000, Pakistan
4 Department of Chemical Engineering, University of Gujrat, Pakistan
Abstract
Hydroxyapatite (HAP) belongs to the family of Ca apatite. Its natural composition and structure are similar to the inorganic phase of natural bone and teeth and has a wide range of applications in the biomedical field, because of its exceptional biocompatibility, bioactivity, and biodegradability. Due to these properties, it is extensively used as implant material in bone tissue engineering (BTE), for controlled release of drugs, dental implants, toothpaste additive, matrices for bone cement, and so on. In this overview, we focus attention on the composition and structure of HAP, the techniques developed to obtain synthetic HAP, and its utilization in the biomedical field as bone and dental implant, coating material, and drug carrier in particular.