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ISSN 2410-955X - An International Biannual Journal
BIOMEDICAL LETTERS
Thyroid Cancer TC-1: an insight from 3D structure prediction to virtual screening for computational drug design
Shahrukh Hassan 1, Jonathan Javid 1,*, Ayesha Sadiqua 1, Safa Mushtaq 1, Nageen Fatima 1, Amna Mohsin 1, Haseeb Akram 2

1 Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan
2 District Head Quarter Hospital, Chiniot, Pakistan

Abstract
A Thyroid cancer 1 (TC-1) disordered protein overexpressed in thyroid carcinogenesis mainly to vertebrate, and thyroid cancer associated genes do not have a common homology. Its rate of deaths depends upon the type of thyroid cancer 1. The impact of TC-1 in papillary carcinoma showed more expression of thyroid cancer among other tumors. The protein was involved in various biological processes such as wnt/? catenin signaling pathway involved in thyroid cancer. The TC-1 undergoes a detailed sequence analysis that provides the information in conserved part region among primates, birds, rodents, and reptiles. Additionally, different prediction tools and software were utilized for the prediction of thyroid cancer 1 protein. The string database was used for protein- protein analyses that were performed with LSM1 interacting protein and seek the protein interacting residues by computational approach. The comparative docking was performed by utilizing ZINC library compound and generated an efficient result by selecting the compound having least binding affinity for the analysis of computational drug designing.

A R T I C L E  I N F O

Received
March 18, 2020
Revised
April 31, 2020
Accepted
June 10, 2020

*Corresponding Author
Jonathan Javid
E-mail
Jonathanjavid257@gmail.com

Keywords
Thyroid cancer TC-1
Bioinformatics
Transcriptional immune response
Thyroid Cancer



Research article


2020 | Volume 6 | Issue 2: Special issue articles: Computational drug designing and molecular docking analyses