Copyright 2024 The Science Publishers
All Rights Reserved for Website Design.
.png){kind=small}
ISSN 2410-955X - An International Biannual Journal
Computer Aided Drug Designing (CADD): Tools used for structure-based drug designing
Muneeza Maqsood, Yusra Karim*, Eman Fatima, Saliha Marriam, Rameen Afzal
Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan
Abstract
Traditional drug designing utilizing conventional methods is considered to be an exorbitant and time-consuming process. CADD was introduced as an effective method which has enormously increased and economized the drug designing and development process utilizing computational methodologies. CADD can be achieved by ligand-based drug designing (LBDD) and structure-based drug designing (SBDD). It has reduced the time required for a drug to move from its initial stages to the market by utilizing CADD process and its respective methodologies in comparison with the traditional drug designing. In this review, we've discussed the most cited computational tools for 3D structure prediction of target protein along with the tools and scoring techniques to scrutinize molecular docking of target and ligand complex, to achieve novel drugs centered on structure of biological target.
A R T I C L E I N F O
Received
March 29, 2020
Revised
May 12, 2020
Accepted
June 21, 2020
*Corresponding Author
Yusra Karim
E-mail
yusrakareem123@gmail.com
Keywords
Computer aided drug designing
Structure based drug designin
Molecular docking tools
Biological target
Review article
2020 | Volume 6 | Issue 2: Special issue articles: Computational drug designing and molecular docking analyses