Biomedical Letters

Review article | https://doi.org/10.47262/BL/10.1.20231211

Recent progress in the application of biodegradable metal implants

Ahsan Riaz Khan 1, 2*, Muhammad Talha Shabbir 3*, Navdeep Singh Grewal 4, Hai-Jun Zhang 1, 2, Zhang Jun 5

1 Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

2 National United Engineering Laboratory for Biomedical Material Modification, Branden Industrial Park, Qihe Economic & Development Zone, Dezhou City, Shandong, 251100, China

3 deMontmorency College of Dentistry, Lahore, Pakistan

4 Department of Mechanical Engineering, Guru Kashi University, Talwandi Sabo - 151302, India

5 Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China

Abstract

With the accumulation of data, magnesium-based degradable metal, iron-based degradable metal and zinc-based degradable metal implantable interventional devices have entered the clinic or carried out human experimental studies, and the future prospects are promising. In this paper, the definition, biodegradability and biocompatibility criteria and their classification are reviewed, and the research status and unsolved scientific problems of magnesium-based degradable metals, iron-based degradable metals and zinc-based degradable metals are introduced, and the future development opportunities and challenges of degradable metals are prospected. With a deeper understanding of scientific issues such as mechanical adaptation, degradation adaptation and tissue adaptation of degradable metal implants, more new materials, new technologies and new methods of degradable metals will be developed in the future, so as to effectively realize the precise adaptation of the two events of degradable metal material degradation and body tissue repair in time and geometric space.