Biomedical Letters

Characterization of metal (Mg, Ni & Zn) complexes with β-sitosterol for antimicrobial studies

Yasmeen Bibi 1*, Aneela Wahab 1, S. Naseem Shah 2, Samina Satar 1, Atya Hassan 1, Sikandar Khan Sherwani 3, Syed Ahsan Shah 4

1 Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

2 Department of Physics, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

3 Department of Microbiology, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

4 Department of Botany, Hazara University, Mansehra, Pakistan

Abstract

The metal complexes of Mg (II), Ni (II), and Zn (II) with β-sitosterol were synthesized and the obtained complexes were characterized by various techniques such as elemental analysis, Infrared Spectroscopy (IR), UV Visible Spectroscopy (UV VIS), Proton Nuclear Magnetic Resonance (1H-NMR), Electron Dispersive X-ray Spectroscopy (EDX), Scanning Electron Microscopy (SEM) and Thermo Gravimetric Analysis (TGA). From the analytical data, the stoichiometry of all the complexes was found to be a 1:2 (metal: ligand) ratio with the general formula ML2X. The IR spectral data predict that the βs behave as a bidentate ligand with a hydroxyl group (OH) and C=C (double bond) groups pointing towards the central metal ion. The Absorption spectra showed an octahedral ?geometry of the complexes. The EDX features indicated that the desired elements along with their mass percentage ?ratio are present in the metal complexes. The ligand and complexes were screened for their antibacterial, antifungal ?and antioxidant activities. The metal ions present in the complexes accelerate the anti-microbial activity and they ?are more effective than ligands in terms of their biological activity which gives them the opportunity for use in ?medical practice. ?