Science Letters

Surface and micellar properties of Clindamycine Phosphate in aqueous solution

Muhammad Usman 1,4, Zahoor Hussain Farooqi 2,4, Abbas Khan 3,4, Mohammad Siddiq 4,* Muhammad Yameen 5

1 Department of Chemistry, Government College University, Faisalabad, Pakistan

2 Institute of Chemistry, University of the Punjab, Lahore, Pakistan

3 Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan

4 Department of Chemistry, Quaid-i-Azam University, Islamabad

5 Department of Applied Chemistry & Biochemistry, Government College University, Faisalabad, Pakistan

Abstract

This manuscript reports the solution and micellar behaviour of an antibiotic drug Clindamycine Phosphate (CLN) in aqueous media. Surface tension and specific conductivity were used to find the critical micelle concentration (CMC) and in this way its surface and thermodynamic parameters were calculated. The electrical conductivity was measured as a function of concentration at various temperatures and CMC was calculated in the temperature range of 20-50�C. Thermodynamic parameters i.e. standard free energy of micellization, standard enthalpy of micellization, and standard entropy of micellization, were calculated from CMC value using closed association model.

Keywords: Micellization, drug, surface tension, entropy, conductivity, free energy, enthalp.

Received May 25, 2013; Revised July 22, 2013; Accepted August 14, 2013

*Corresponding author: Mohammad Siddiq; Email: m_sidiq12@yahoo.com